Catalyzed reaction/ biological activity
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining (according to Swiss-Prot)Protein family
topo IA family (according to Swiss-Prot)Paralogous protein(s)
[protein|41199C76DF8CA804B7B8878D61228B9542A96AE4|TopA][SW|Domains]
N-terminal [SW|TOPRIM domain] (aa 3-136) [Pubmed|9722641]Effectors of protein activity
[protein|search|RecQ ]controls [protein|7D5327BD1DD5FD5F90B2C849589923AA3D8B20EF|Topo III] (de)catenation activity [pubmed|11497238,10360177]Structure
[PDB|1D6M] (from ''E. coli'', 33% identity) [Pubmed|10574789]Mutant
MGNA-C111 (topB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2109 NBRP B. subtilis, Japan]BKE04260 (''topB''::''ermC'') (available at the [http://www.bgsc.org/ BGSC] and in [SW|Jörg Stülke]'s lab) [pubmed|28189581]GP1864 (''topB''::''ermC'') (available in [SW|Jörg Stülke]'s lab)GP1896 (''topB''::''cat'') (available in [SW|Jörg Stülke]'s lab)JH642 and its derivatives: natural deletion of the 18 kb [gene|467E9CF20B545A976614968E7DD5497F9390D344|ydzA]-[gene|353DADE8E57A0F1895CCEB62701F9273EEB5EB45|mntH] region encompassing the genes [gene|467E9CF20B545A976614968E7DD5497F9390D344|ydzA]-[gene|7D5327BD1DD5FD5F90B2C849589923AA3D8B20EF|topB]-[gene|69DEE29383E40F49890CC8314DFBF56D70D35113|ydaJ]-[gene|70ED3CE683F3A3F785480F40986CABE7729C17C7|ydaK]-[gene|28D80C5497AE29A24AD6B9A1A713A2B3915F2CED|ydaL]-[gene|961538BEDD27C24FC073AFB7AB3268E3D46783CC|ydaM]-[gene|ADE0122D8FFF2F78B6D21031B7D02A323A13ED63|ydaN]-[gene|5968E6D4D7378C69EC3E1E05B285069123AA1FD3|kimA]-[gene|6085BDAD40F719555EA4EEA7BBAD74103BD03D0F|mutT]-[gene|2883FC60CD69948D5C43BDDFEFBE7A1CA7C743C7|ydaP]-[gene|87834D5C47064BEFF26F086A8202C311F28F9D38|ydzK]-[gene|search|mntH ][pubmed|18670626]BKE04260 (Δ[gene|7D5327BD1DD5FD5F90B2C849589923AA3D8B20EF|topB]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE04260 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGCTTGATCACTTCTCTT, downstream forward: _UP4_TAATAAAAAAACCTGTGCCTBKK04260 (Δ[gene|7D5327BD1DD5FD5F90B2C849589923AA3D8B20EF|topB]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK04260 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGCTTGATCACTTCTCTT, downstream forward: _UP4_TAATAAAAAAACCTGTGCCT